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Article

Structural basis for the cell-specific activities of the NGFI-B and the Nurr1 ligand-binding domain.

The Journal of biological chemistry - 13 May 2005

Flaig Ralf, Greschik Holger, Peluso-Iltis Carole, Moras Dino

Abstract excerpt

NGFI-B is a ligand-independent orphan nuclear receptor of the NR4A subfamily that displays important functional differences with its homolog Nurr1. In particular, the NGFI-B ligand-binding domain (LBD) exhibits only modest activity in cell lines in which the Nurr1 LBD strongly activates transcription. To gain insight into the structural basis for the distinct activation potentials, we determined the crystal...

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PMID: 15716272
DOI: 10.1074/jbc.M413175200

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