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Article

The crystal structure of the orphan nuclear receptor NR2E3/PNR ligand binding domain reveals a dimeric auto-repressed conformation.

PloS one - 1 Jan 2013

Tan M H Eileen, Zhou X Edward, Soon Fen-Fen, Li Xiaodan, Li Jun, Yong Eu-Leong, Melcher Karsten, Xu H Eric

Abstract excerpt

Photoreceptor-specific nuclear receptor (PNR, NR2E3) is a key transcriptional regulator of human photoreceptor differentiation and maintenance. Mutations in the NR2E3-encoding gene cause various retinal degenerations, including Enhanced S-cone syndrome, retinitis pigmentosa, and Goldman-Favre disease. Although physiological ligands have not been identified, it is believed that binding of small molecule agonists,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24069298
DOI: 10.1371/journal.pone.0074359
PMCID: PMC3771917

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Source receipt: pubmed, retrieved 7 Sept 2026.

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