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Article

Characterization of the Nurr1 ligand-binding domain co-activator interaction surface.

Journal of molecular endocrinology - 1 Oct 2006

Volakakis Nikolaos, Malewicz Michal, Kadkhodai Banafsheh, Perlmann Thomas, Benoit Gerard

Abstract excerpt

The recently solved crystal structure of the orphan nuclear receptor (NR) Nurr1 ligand-binding domain (LBD) showed that Nurr1 lacks a cavity for ligand binding and a canonical NR co-activator-binding site. Computer modeling of the Nurr1 LBD structure identified a hydrophobic region on the surface of the Nurr1 LBD that was positioned on the opposite side from the classical co-activator-binding site. Site-directed...

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PMID: 17032747
DOI: 10.1677/jme.1.02106

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Source receipt: pubmed, retrieved 7 Sept 2026.

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