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Article

Graded activation of mutant K41C-KCNE1:KCNQ1 channel complexes by mefenamic acid.

Channels (Austin, Tex.) - 1 Dec 2025

Wang Yundi, Chan Magnus, Pourrier Marc, Eldstrom Jodene, Fedida David

Abstract excerpt

The IKs current formed by the co-assembly of KCNE1 and KCNQ1 plays an important role in cardiac repolarization. Mefenamic acid, an NSAID, is known to enhance IKs currents and has in turn been suggested as a therapeutic starting point for the development of compounds for the treatment of long QT syndrome. Our previous examinations of mefenamic acid's action revealed that residue K41 on KCNE1 was critical for...

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Share to Anti-Inflammatory Agents, Non-Steroidal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40729370
DOI: 10.1080/19336950.2025.2539494
PMCID: PMC12309529

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Graded activation of mutant K41C-KCNE1:KCNQ1 channel complexes by mefenamic acid.PMID 40729370Read ↗

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