Article
Action potential clamp and mefloquine sensitivity of recombinant 'I KS' channels incorporating the V307L KCNQ1 mutation.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society - 1 Apr 2010
El Harchi A, McPate M J, Zhang Y H, Zhang H, Hancox J C
Abstract excerpt
The slow delayed rectifier potassium current, 'I(Ks)', contributes to repolarisation of cardiac ventricular action potentials and thereby to the duration of the QT interval of the electrocardiogram. Mutations to I(Ks) channel subunits occur in clinically significant cardiac repolarisation disorders. The short QT syndrome (SQTS) is associated with accelerated ventricular repolarisation and with an increased risk...
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