A novel random forest integrative approach based on endogenous CYP3A4 phenotype for predicting tacrolimus concentrations and dosages in Chinese renal transplant patients.

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVE: Personalized treatment with tacrolimus has remained a challenge. The present study aimed to evaluate the potential of an integrative approach to predict individual tacrolimus concentrations and dosages based on endogenous CYP3A4 phenotype, CYP3A5 genotype and clinical variables. METHODS: A random forest (RF) algorithm which incorporated an endogenous CYP3A4 phenotype (assessed by...

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