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Article

Tacrolimus population pharmacokinetic models according to CYP3A5/CYP3A4/POR genotypes in Chinese Han renal transplant patients.

Pharmacogenomics - 1 Aug 2018

Zhu Wan, Xue Ling, Peng Hongwei, Duan Zhouping, Zheng Xuelian, Cao Duanwen, Wen Jinhua, Wei Xiaohua

Abstract excerpt

AIM: To develop a population pharmacokinetic (PK) model of tacrolimus in Chinese Han renal transplant population and establish the influence of different covariates (especially different CYP3A5/3A4/POR genotype) on PK properties. MATERIALS & METHODS: Trough tacrolimus concentrations, clinical characteristics and CYP3A5/CYP3A4/POR genotypes were collected from 141 adult renal transplant recipients after...

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PMID: 30040022
DOI: 10.2217/pgs-2017-0139

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POR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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