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Article

Machine learning-based method for tacrolimus dose predictions in Chinese kidney transplant perioperative patients.

Journal of clinical pharmacy and therapeutics - 1 May 2022

Fu Qun, Jing Yan, Liu Mr Guozhen, Jiang Mr Xuehui, Liu Hong, Kong Ying, Hou Xiongjun, Cao Lei, Deng Pei, Xiao Pin, Xiao Jiansheng, Peng Hongwei, Wei Xiaohua

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVES: Tacrolimus (TAC), a first-line immunosuppressant in solid-organ transplant, has a narrow therapeutic window and large inter-individual variability, which affects its use in clinical practice. Successful predictions using machine learning algorithms have been reported in several fields. However, a comparison of 10 machine learning model-based TAC pharmacogenetic and pharmacokinetic...

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PMID: 34802160
DOI: 10.1111/jcpt.13579

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