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Article

Donor and recipient P450 gene polymorphisms influence individual pharmacological effects of tacrolimus in Chinese liver transplantation patients.

International immunopharmacology - 1 Apr 2018

Liu Jianyu, Ouyang Yabo, Chen Dexi, Yao Bo, Lin Dongdong, Li Zhiqiang, Zang Yunjin, Liu Huan, Fu Xiaoyue

Abstract excerpt

The immunosuppressant drug tacrolimus (Tac) used for the prevention of immunological rejection is a metabolic substrate of cytochrome P450 enzymes. This study was designed to evaluate the short-term and long-term potential influence of single-nucleotide polymorphisms (SNPs) in CYP450 genes of liver transplant (LT) recipients as well as the donors on individual pharmacological effects of Tac and to guide...

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Identifiers

PMID: 29454235
DOI: 10.1016/j.intimp.2018.02.005

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