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Article

Population pharmacokinetics of tacrolimus in Chinese adult liver transplant patients.

Biopharmaceutics & drug disposition - 1 Apr 2022

Teng Fei, Zhang Weiyue, Wang Wei, Chen Jiani, Liu Shiyi, Li Mingming, Li Lujin, Guo Wenyuan, Wei Hua

Abstract excerpt

Tacrolimus is widely used in organ transplantation to prevent rejection. However, the narrow therapeutic window and the large inter-and intra-individual variability in the pharmacokinetics (PK) of tacrolimus make it difficult for individualization of dosing. This study aimed at developing a population pharmacokinetic model for estimating the oral clearance of tacrolimus in Chinese liver transplant patients, and...

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PMID: 35220592
DOI: 10.1002/bdd.2311

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