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Enhanced pathogenicity and transmissibility of H9N2 avian influenza virus in mammals by hemagglutinin mutations combined with PB2-627K.

Virologica Sinica - 1 Feb 2023

Liu Kaituo, Guo Yaqian, Zheng Huafen, Ji Zhuxing, Cai Miao, Gao Ruyi, Zhang Pinghu, Liu Xiaowen, Xu Xiulong, Wang Xiaoquan, Liu Xiufan

Abstract excerpt

H9N2 avian influenza viruses (AIVs) circulate globally in poultry and have become the dominant AIV subtype in China in recent years. Previously, we demonstrated that the H9N2 virus (A/chicken/Eastern China/SDKD1/2015) naturally harbors a mammalian-adaptive molecular factor (627K) in the PB2 protein and is weakly pathogenic in mice. Here, we focused on new markers for virulence in mammals. A mouse-adapted H9N2...

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Identifiers

PMID: 36103978
DOI: 10.1016/j.virs.2022.09.006
PMCID: PMC10006187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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