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Article

Molecular basis of efficient replication and pathogenicity of H9N2 avian influenza viruses in mice.

PloS one - 1 Jan 2012

Li Xiaokang, Qi Wenbao, He Jun, Ning Zhangyong, Hu Yue, Tian Jin, Jiao Peirong, Xu Chenggang, Chen Jianxin, Richt Juergen, Ma Wenjun, Liao Ming

Abstract excerpt

H9N2 subtype avian influenza viruses (AIVs) have shown expanded host range and can infect mammals, such as humans and swine. To date the mechanisms of mammalian adaptation and interspecies transmission of H9N2 AIVs remain poorly understood. To explore the molecular basis determining mammalian adaptation of H9N2 AIVs, we compared two avian field H9N2 isolates in a mouse model: one (A/chicken/Guangdong/TS/2004, TS)...

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Identifiers

PMID: 22768236
DOI: 10.1371/journal.pone.0040118
PMCID: PMC3387007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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