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Article

Pig-a mutations in bone marrow erythroblasts of rats treated with 7,12-dimethyl-benz[a]anthracene.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 Dec 2019

Revollo Javier R, Dad Azra, Pearce Mason G, Mittelstaedt Roberta A, Robison Timothy W, Dobrovolsky Vasily N

Abstract excerpt

Flow cytometry-based phenotypic detection of red blood cells (RBCs) deficient in surface markers anchored by glycosylphosphatidylinositol (GPI) is an efficient tool for monitoring somatic mutation in mammalian species. Biochemical considerations suggest that GPI-anchored marker-deficient RBCs found in peripheral blood are due to mutations in the endogenous X-linked phosphatidylinositolglycan, class A gene (Pig-a...

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PMID: 31708078
DOI: 10.1016/j.mrgentox.2019.503106

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