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Article

Erythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential.

Mutation research - 8 Dec 2008

Phonethepswath Souk, Bryce Steven M, Bemis Jeffrey C, Dertinger Stephen D

Abstract excerpt

Glycosylphosphatidylinositol (GPI) anchors attach specific proteins to the cell surface of hematopoietic cells. Of the genes required to form GPI anchors, only Pig-a is located on the X-chromosome. Prior work with rats suggests that the GPI anchor deficient phenotype is a reliable indicator of Pig-a mutation [Bryce et al., Environ. Mol. Mutagen., 49 (2008) 256-264]. The current report extends this line of...

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Identifiers

PMID: 18790079
DOI: 10.1016/j.mrgentox.2008.08.011
PMCID: PMC2628466

Genes

GPI

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