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Article

TOX3 gene variant could be associated with painful restless legs.

Sleep medicine - 1 Jan 2020

Karroum Elias G, Saini Prabhjyot S, Trotti Lynn M, Rye David B

Abstract excerpt

BACKGROUND/OBJECTIVE: Restless legs syndrome (RLS) is a neurological disorder with a strong genetic susceptibility. A painful RLS sub-phenotype has been described previously but the neurobiological basis for this phenotypic variant remains unknown. This study investigated whether any of the six initially discovered genomic loci associating with RLS (BTBD9, MEIS1, PTPRD, MAP2K5/SKOR1, TOX3, and an intergenic...

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Identifiers

PMID: 31706190
DOI: 10.1016/j.sleep.2019.07.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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