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Article

TOX3 Variants Are Involved in Restless Legs Syndrome and Parkinson's Disease with Opposite Effects.

Journal of molecular neuroscience : MN - 1 Mar 2018

Mohtashami Sadaf, He Qin, Ruskey Jennifer A, Zhou Sirui, Dion Patrick A, Allen Richard P, Earley Christopher J, Fon Edward A, Xiong Lan, Dupre Nicolas, Dauvilliers Yves, Rouleau Guy A, Gan-Or Ziv

Abstract excerpt

Parkinson's disease (PD) and restless legs syndrome (RLS) may be clinically and/or etiologically related, yet this association is under debate. Single-nucleotide polymorphisms (SNPs) in the TOX3 gene locus were implicated in both RLS and PD genome-wide association studies (GWASs), suggesting a potential pleiotropy. Two case-control cohorts including 644 PD patients, 457 RLS patients, and 945 controls were...

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Identifiers

PMID: 29404899
DOI: 10.1007/s12031-018-1031-4

Genes

TOX3

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