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Article

Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD.

Sleep - 1 Sept 2014

Moore Hyatt, Winkelmann Juliane, Lin Ling, Finn Laurel, Peppard Paul, Mignot Emmanuel

Abstract excerpt

STUDY OBJECTIVES: To examine association between periodic leg movements (PLM) and 13 single nucleotide polymorphisms (SNPs) in 6 loci known to increase risk of restless legs syndrome (RLS). SETTING: Stanford Center for Sleep Sciences and Medicine and Clinical Research Unit of University of Wisconsin Institute for Clinical and Translational Research. PATIENTS: Adult participants (n = 1,090, mean age = 59.7 years)...

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Source

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Identifiers

PMID: 25142570
DOI: 10.5665/sleep.4006
PMCID: PMC4153066

Genes

BTBD9
MEIS1
TOX3
PTPRD
SKOR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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