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Article

Revisiting multifocal breast cancer: a clonality study of ductal carcinoma using whole exome sequencing.

Human pathology - 1 Dec 2019

Schwartz Christopher J, Dolgalev Igor, Vasudevaraja Varshini, Kelly Stephen, Heguy Adriana, Snuderl Matija, Cotzia Paolo, Jour George, Darvishian Farbod

Abstract excerpt

Multifocal breast cancer (MFBC), ductal type, has been hypothesized to arise by one of two mechanisms: either through intramammary/intralymphatic spread from a single index tumor (MBC-1), or as multiple independent tumors with each focus carrying its corresponding ductal carcinoma in-situ (MBC-2). In order to improve our understanding of MFBC pathogenesis, we employed laser capture microdissection coupled with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31704365
DOI: 10.1016/j.humpath.2019.08.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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