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Article

Intratumor Heterogeneity of Synchronous In Situ and Invasive Breast Carcinoma Revealed Using Multi-region Exome Sequencing.

Anticancer research - 1 Aug 2021

Kim Hayeon, Gim Jeong-An, Kim Chung-Yeul, Kim Aeree

Abstract excerpt

BACKGROUND/AIM: Intratumor heterogeneity (ITH), defined as a tumor composed of multiple subclones with different characteristics, is widely reported in invasive breast carcinoma (IBC) and ductal carcinoma in situ (DCIS). This study aimed to assess the extent of ITH in synchronous DCIS-IBC at the genetic level. MATERIALS AND METHODS: A total of 17 lesions from 5 patients were subjected to whole-exome sequencing....

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Share to Carcinoma, Ductal, Breast
Share to Carcinoma, Intraductal, Noninfiltrating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Core Binding Factor Alpha 2 Subunit

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Share to Receptor-Like Protein Tyrosine Phosphatases, Class 2

Source

Identifiers

PMID: 34281837
DOI: 10.21873/anticanres.15170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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