Uncovering the genomic heterogeneity of multifocal breast cancer.

doi:10.1002/path.4540

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Article

Uncovering the genomic heterogeneity of multifocal breast cancer.

The Journal of pathology - 1 Aug 2015

Desmedt Christine, Fumagalli Debora, Pietri Elisabetta, Zoppoli Gabriele, Brown David, Nik-Zainal Serena, Gundem Gunes, Rothé Françoise, Majjaj Samira, Garuti Anna, Carminati Enrico, Loi Sherene, Van Brussel Thomas, Boeckx Bram, Maetens Marion, Mudie Laura, Vincent Delphine, Kheddoumi Naima, Serra Luigi, Massa Ilaria, Ballestrero Alberto, Amadori Dino, Salgado Roberto, de Wind Alexandre, Lambrechts Diether, Piccart Martine, Larsimont Denis, Campbell Peter J, Sotiriou Christos

Abstract excerpt

Multifocal breast cancer (MFBC), defined as multiple synchronous unilateral lesions of invasive breast cancer, is relatively frequent and has been associated with more aggressive features than unifocal cancer. Here, we aimed to investigate the genomic heterogeneity between MFBC lesions sharing similar histopathological parameters. Characterization of different lesions from 36 patients with ductal MFBC involved...

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Identifiers

PMID: 25850943
DOI: 10.1002/path.4540
PMCID: PMC4691324

Genes

GATA3
PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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