Article
Characterization of Human CD8αβ Interaction With Classical and Unconventional MHC Molecules.
European journal of immunology - 1 Jan 2025
de Wet Ben, Simmons Robert Alan, Suckling Richard J, Szoke-Kovacs Rita, Mansour Salah, Lepore Marco, Cole David K, Jaworski Jakub, Chapman Alexandra L, Aleksic Milos
Abstract excerpt
The CD8 co-receptor exists as both an αα homodimer, expressed on subsets of specialized lymphoid cells, and as an αβ heterodimer, which is the canonical co-receptor on cytotoxic T-cells, tuning TCR thymic selection and antigen-reactivity in the periphery. However, the biophysical parameters governing human CD8αβ interactions with classical MHC class I (MHCI) and unconventional MHC-like molecules have not been...
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