Article
Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study.
BMC cancer - 8 Nov 2019
Shi Xiaodong, Yang Ying, Shang Siqi, Wu Songfang, Zhang Weina, Peng Lijun, Huang Ting, Zhang Ruihong, Ren Ruibao, Mi Jianqing, Wang Yueying
Abstract excerpt
BACKGROUND: DNMT3A R882H, a frequent mutation in acute myeloid leukemia (AML), plays a critical role in malignant hematopoiesis. Recent findings suggest that DNMT3A mutant acts as a founder mutation and requires additional genetic events to induce full-blown AML. Here, we investigated the cooperation of mutant DNMT3A and NRAS in leukemogenesis by generating a double knock-in (DKI) mouse model harboring both...
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