Article

An integrated in silico-in vitro workflow for discovering high-affinity, selective antibodies to the KRAS(G12D)-MHC I complex

2025-09-04

Abstract excerpt

Antibodies that recognize peptide–loaded class I major histocompatibility complex (pMHC I) molecules could enable therapeutic targeting of intracellular oncogenic proteins, yet their discovery has been hampered by the small size of peptide antigens and allele-specificity. We describe an integrated in silico–in vitro workflow for generating high-affinity, selective antibodies to KRAS(G12D) 10 presented by HLA-C*08...

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Literature Corpus work: ef71eabb-8166-501f-bc05-3c6f1f92e300
DOI: 10.1101/2025.08.31.673313

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