Article

Disease-associated Kv1.3 variants are energy compromised with impaired nascent chain folding

2025-01-18

Abstract excerpt

<h4>ABSTRACT</h4> Human Kv1.3, encoded by KCNA3 , is expressed in neuronal and immune cells. Its impaired expression or function produces chronic inflammatory disease and autoimmune disorders, the severity of which correlates with Kv1.3 protein expression. The intersubunit recognition domain, T1, at the cytosolic N-terminus of Kv1.3, acquires secondary, tertiary, and quaternary structures during early biogenesis...

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Literature Corpus work: ca1e12a8-748a-5203-b451-7f1ce377eadd
DOI: 10.1101/2025.01.17.631970

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