Mathematical investigation of HBeAg seroclearance.

doi:10.3934/mbe.2019382

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Article

Mathematical investigation of HBeAg seroclearance.

Mathematical biosciences and engineering : MBE - 20 Aug 2019

Kadelka Sarah, Ciupe Stanca M

Abstract excerpt

Spontaneous or drug-induced loss of hepatitis B e antigen is considered a beneficial event in the disease progression of chronic hepatitis B virus infections. Mathematical models of within-host interactions are proposed; which provide insight into hepatitis B e antibody formation, its influence on hepatitis B e antigen seroclearance, and reversion of anergic cytotoxic immune responses. They predict that antibody...

Topics

Adaptive Immunity
Antiviral Agents
Cell Proliferation
Disease Progression
Hepatitis B e Antigens
Hepatitis B virus
Hepatitis B, Chronic
Hepatocytes
Humans
Immune System
Immunologic Memory
Models, Theoretical
Mutation
Phagocytes
Phagocytosis
Time Factors

Source

Open in PubMed

Identifiers

PMID: 31698631
DOI: 10.3934/mbe.2019382

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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