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Multiscale modeling of HBV infection integrating intra- and intercellular viral propagation to analyze extracellular viral markers

11 Mar 2024

Abstract excerpt

Chronic infection with hepatitis B virus (HBV) is caused by the persistence of closed circular DNA (cccDNA) in the nucleus of infected hepatocytes. Despite available therapeutic anti-HBV agents, eliminating the cccDNA remains challenging. Thus, quantifying and understanding the dynamics of cccDNA are essential for developing effective treatment strategies and new drugs. However, such study requires repeated liver...

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PMID: 38466770
DOI: 10.1371/journal.pcbi.1011238

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