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Article

The clinical significance and optimization strategies of HBeAg seroclearance in chronic hepatitis B treatment.

Frontiers in cellular and infection microbiology - 1 Jan 2026

Zhang Yaqin, Gao Yuanjiao, Li Xinxin, Zhang Ziyu, Wang Shiyu, Gao Zixuan, Xie Yao, Li Minghui

Abstract excerpt

HBeAg seroclearance represents a critical milestone in the treatment of HBeAg-positive chronic hepatitis B (CHB), which is closely associated with disease remission, functional cure, and reduced hepatocellular carcinoma risk. As HBeAg is a secreted viral protein associated with active HBV replication, infectivity, and host immune tolerance, its disappearance usually indicates a transition toward improved immune...

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Share to Antiviral Agents
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Hepatitis B, Chronic

Share to Hepatitis B e Antigens

Share to Hepatitis B virus

Share to Liver Neoplasms

Source

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Identifiers

PMID: 42445855
DOI: 10.3389/fcimb.2026.1785154
PMCID: PMC13357521

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