Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mathematical models of e-antigen mediated immune tolerance and activation following prenatal HBV infection.

PloS one - 1 Jan 2012

Ciupe Stanca M, Hews Sarah

Abstract excerpt

We develop mathematical models for the role of hepatitis B e-antigen in creating immunological tolerance during hepatitis B virus infection and propose mechanisms for hepatitis B e-antigen clearance, subsequent emergence of a potent cellular immune response, and the effect of these on liver damage. We investigate the dynamics of virus-immune cells interactions, and derive parameter regimes that allow for viral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis B
Share to Hepatitis B e Antigens
Share to Hepatitis B virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune Tolerance

Share to Immunity, Cellular

Share to Maternal-Fetal Exchange

Share to Models, Immunological

Share to Pregnancy Complications, Infectious

Source

Open in PubMed Open full text

Identifiers

PMID: 22768303
DOI: 10.1371/journal.pone.0039591
PMCID: PMC3388102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mathematical models of e-antigen mediated immune tolerance and activation following prenatal HBV infection.PMID 22768303Read ↗

Mathematical Models of Early Hepatitis B Virus Dynamics in Humanized MiceSemantic proximity Read ↗

Age-Dependent Outcomes of HBV Infection: An Integrated Conceptual Framework Linking Developmental Immunity, Tpex Dynamics, and Longitudinal Clinical ObservationsSemantic proximity Read ↗

Mathematical investigation of HBeAg seroclearance.Semantic proximity Read ↗

Hepatitis B virus replication and mutation are autoregulated by interactions between surface antigen and HBeAg and the HBV DNA polymerase: a functional model with therapeutic implications.Semantic proximity Read ↗

Predictions of the emergence of vaccine-resistant hepatitis B in The Gambia using a mathematical model.Semantic proximity Read ↗

Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical TransmissionSemantic proximity Read ↗

Current status of HBV vaccine escape variants--a mathematical model of their epidemiology.Semantic proximity Read ↗

Germinal center dynamics during acute and chronic infection.Semantic proximity Read ↗

Envelope and precore/core variants of hepatitis B virus.Semantic proximity Read ↗

Dynamics of a delay differential equation model of hepatitis B virus infectionSemantic proximity Read ↗

Modeling complex decay profiles of hepatitis B virus during antiviral therapy†‡Semantic proximity Read ↗

Factors affecting the natural decay of hepatitis B surface antigen in children with chronic hepatitis B virus infection during long-term follow-up.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.