Hepatitis B virus replication and mutation are autoregulated by interactions between surface antigen and HBeAg and the HBV DNA polymerase: a functional model with therapeutic implications.

Abstract excerpt

Infection with hepatitis B virus can result in asymptomatic seroconversion with viral clearance, fulminant hepatic failure and death, or chronic, typically lifelong, transmissible infection. The mechanism(s) of viral persistence are poorly understood but viral clearance and fulminant hepatic fail...

Topics

• DNA-Directed DNA Polymerase
• Hepatitis B
• Hepatitis B Surface Antigens
• Hepatitis B e Antigens
• Hepatitis B virus
• Homeostasis
• Humans
• Models, Biological
• Models, Structural
• Mutation
• Protein Conformation