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Article

Replication timing alterations in leukemia affect clinically relevant chromosome domains.

Blood advances - 12 Nov 2019

Rivera-Mulia Juan Carlos, Sasaki Takayo, Trevilla-Garcia Claudia, Nakamichi Naoto, Knapp David J H F, Hammond Colin A, Chang Bill H, Tyner Jeffrey W, Devidas Meenakshi, Zimmerman Jared, Klein Kyle N, Somasundaram Vivek, Druker Brian J, Gruber Tanja A, Koren Amnon, Eaves Connie J, Gilbert David M

Abstract excerpt

Human B-cell precursor acute lymphoid leukemias (BCP-ALLs) comprise a group of genetically and clinically distinct disease entities with features of differentiation arrest at known stages of normal B-lineage differentiation. We previously showed that BCP-ALL cells display unique and clonally heritable, stable DNA replication timing (RT) programs (ie, programs describing the variable order of replication and...

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Identifiers

PMID: 31698451
DOI: 10.1182/bloodadvances.2019000641
PMCID: PMC6855107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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