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Article

The circadian clock circuitry modulates leukemia initiating cell activity in T-cell acute lymphoblastic leukemia

24 Aug 2023

Abstract excerpt

BACKGROUND: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy, characterized by restricted cellular subsets with asymmetrically enriched leukemia initiating cell (LIC) activity. Nonetheless, it is still unclear which signaling programs promote LIC maintenance and progression. METHODS: Here, we evaluated the role of the biological clock in the regulation of the molecular...

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PMID: 37620852
DOI: 10.1186/s13046-023-02799-7

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