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The Magnitude of Telomere Shortening per Cell Division In Vivo: Implications for Lifelong Hematopoiesis in Humans

2025-04-21

Abstract excerpt

The magnitude of telomere shortening per cell division in human somatic cells in vivo (MTS IV ) is a fundamental but unquantified parameter. MTS IV is essential for understanding how telomere-length (TL)-dependent hematopoietic cell division influences age-related health and longevity. By leveraging sex differences in leukocyte TL and the differential dosage of DKC1 , a telomerase-regulating gene, during early...

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Literature Corpus work
b4c30f1b-c63f-511a-8439-6ef26e77ae99
DOI
10.1101/2025.04.16.649166
Open publication

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The Magnitude of Telomere Shortening per Cell Division In Vivo: Implications for Lifelong Hematopoiesis in HumansDOI 10.1101/2025.04.16.649166
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