Article
Concordance for clonal hematopoiesis is limited in elderly twins.
Blood - 23 Jan 2020
Fabre Margarete A, McKerrell Thomas, Zwiebel Maximillian, Vijayabaskar M S, Park Naomi, Wells Philippa M, Rad Roland, Deloukas Panagiotis, Small Kerrin, Steves Claire J, Vassiliou George S
Abstract excerpt
Although acquisition of leukemia-associated somatic mutations by 1 or more hematopoietic stem cells is inevitable with advancing age, its consequences are highly variable, ranging from clinically silent clonal hematopoiesis (CH) to leukemic progression. To investigate the influence of heritable factors on CH, we performed deep targeted sequencing of blood DNA from 52 monozygotic (MZ) and 27 dizygotic (DZ) twin...
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