Article
Clonal hematopoiesis in sickle cell disease
2021-06-15
Abstract excerpt
Curative gene therapies for sickle cell disease (SCD) are currently undergoing clinical evaluation. However, the occurrence of several myeloid malignancy cases in these trials has prompted safety concerns. Individuals with SCD are predisposed to myeloid malignancies, but the underlying causes remain undefined. Clonal hematopoiesis (CH) is a pre-malignant condition that also confers significant predisposition to my...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 46c6ffb5-b764-5141-9721-10663d5af57f
- DOI
- 10.1101/2021.06.12.21258772