Article
Clonal hematopoiesis in elderly twins: concordance, discordance, and mortality.
Blood - 23 Jan 2020
Hansen Jakob Werner, Pedersen Dorthe Almind, Larsen Lisbeth Aagaard, Husby Simon, Clemmensen Signe Bedsted, Hjelmborg Jacob, Favero Francesco, Weischenfeldt Joachim, Christensen Kaare, Grønbæk Kirsten
Abstract excerpt
Clonal hematopoiesis (CH) of indeterminate potential (CHIP) is defined by mutations in myeloid cancer-associated genes with a variant allele frequency of at least 2%. Recent studies have suggested a possible genetic predisposition to CH. To further explore this phenomenon, we conducted a population-based study of 594 twins from 299 pairs aged 73 to 94 years, all with >20 years' follow-up. We sequenced DNA from...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.