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Article

Clonal hematopoiesis in sickle cell disease

6 Jan 2022

Abstract excerpt

BACKGROUNDCurative gene therapies for sickle cell disease (SCD) are currently undergoing clinical evaluation. The occurrence of myeloid malignancies in these trials has prompted safety concerns. Individuals with SCD are predisposed to myeloid malignancies, but the underlying causes remain undefined. Clonal hematopoiesis (CH) is a premalignant condition that also confers significant predisposition to myeloid...

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PMID: 34990411
DOI: 10.1172/jci156060

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