Article
Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade.
Blood - 26 Dec 2019
Chapuy Bjoern, Stewart Chip, Dunford Andrew J, Kim Jaegil, Wienand Kirsty, Kamburov Atanas, Griffin Gabriel K, Chen Pei-Hsuan, Lako Ana, Redd Robert A, Cote Claire M, Ducar Matthew D, Thorner Aaron R, Rodig Scott J, Getz Gad, Shipp Margaret A
Abstract excerpt
Primary mediastinal large B-cell lymphomas (PMBLs) are aggressive tumors that typically present as large mediastinal masses in young women. PMBLs share clinical, transcriptional, and molecular features with classical Hodgkin lymphoma (cHL), including constitutive activation of nuclear factor κB (NF-κB), JAK/STAT signaling, and programmed cell death protein 1 (PD-1)-mediated immune evasion. The demonstrated...
Topics
- Adult
- Antineoplastic Agents, Immunological
- Biomarkers, Tumor
- Cohort Studies
- DNA Copy Number Variations
- Female
- Gene Expression Regulation, Neoplastic
- Genomics
- Humans
- Lymphoma, Large B-Cell, Diffuse