Clinical Applications of the Genomic Landscape of Aggressive Non-Hodgkin Lymphoma.

Abstract excerpt

In this review, we examine the genomic landscapes of lymphomas that arise from B, T, and natural killer cells. Lymphomas represent a striking spectrum of clinical behaviors. Although some lymphomas are curable with standard therapy, the majority of the affected patients succumb to their disease. Here, the genetic underpinnings of these heterogeneous entities are reviewed. We consider B-cell lymphomas, including...

Topics

• Genomics
• Humans
• Lymphoma, Non-Hodgkin
• Molecular Targeted Therapy
• Mutation
• Signal Transduction