Article
Next generation sequencing and the management of diffuse large B-cell lymphoma: from whole exome analysis to targeted therapy.
Discovery medicine - 1 Jan 2000
Jardin Fabrice
Abstract excerpt
Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma, accounting for 30-40% of newly diagnosed non-Hodgkin lymphomas. Historically, DLBCL has been thought to involve recurrent translocations of the IGH gene and the deregulation of rearranged oncogenes. Recent advances in next generation sequencing (NGS) have provided a vast and comprehensive catalogue of cancer genes involved in DLBCL...
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