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Article

Activating mutations affecting the NF-kappa B pathway and EZH2-mediated epigenetic regulation are rare events in primary mediastinal large B-cell lymphoma.

Anticancer research - 1 Oct 2014

Gebauer Niklas, Hardel Tim Tristan, Gebauer Judith, Bernard Veronica, Merz Hartmut, Feller Alfred C, Rades Dirk, Biersack Harald, Lehnert Hendrik, Thorns Christoph

Abstract excerpt

BACKGROUND: Primary mediastinal large B-cell lymphoma (PMBL) is a distinct subtype of diffuse large B-cell lymphoma (DLBCL) frequently observed in young patients. High-dose immunochemotherapy constitutes the current therapeutic gold-standard, despite significant toxicity and serious late effects. Several hotspots harboring oncogenic gain-of-function mutations were recently shown to pose vital hallmarks in...

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Share to Enhancer of Zeste Homolog 2 Protein
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lymphoma, Large B-Cell, Diffuse

Share to Mediastinal Neoplasms

Share to Mutation Rate

Share to NF-kappa B

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Share to Polycomb Repressive Complex 2

Source

Identifiers

PMID: 25275047

Genes

CARD11
MYD88
BCR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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