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Article

Activating somatic mutations in diffuse large B-cell lymphomas: lessons from next generation sequencing and key elements in the precision medicine era.

Leukemia & lymphoma - 1 May 2015

Bohers Elodie, Mareschal Sylvain, Bertrand Philippe, Viailly Pierre Julien, Dubois Sydney, Maingonnat Catherine, Ruminy Philippe, Tilly Hervé, Jardin Fabrice

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma, accounting for 30-40% of newly diagnosed non-Hodgkin lymphomas. Historically, DLBCL has been thought to involve recurrent translocations of the immunoglobulin heavy (IGH) locus and the deregulation of rearranged oncogenes. Whole exome sequencing (WES) of more than 200 DLBCLs has completely redefined the genetic landscape of the disease by...

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Source

Identifiers

PMID: 25130477
DOI: 10.3109/10428194.2014.941836

Genes

BCR
CARD11
IGH
MYD88

Provenance

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