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A cross-tissue transcriptome-wide association study identifies novel susceptibility genes for lung cancer in Chinese populations.

Human molecular genetics - 12 Aug 2021

Zhu Meng, Fan Jingyi, Zhang Chang, Xu Jing, Yin Rong, Zhang Erbao, Wang Yuzhuo, Ji Mengmeng, Sun Qi, Dai Juncheng, Jin Guangfu, Chen Liang, Xu Lin, Hu Zhibin, Ma Hongxia, Shen Hongbing

Abstract excerpt

Although dozens of susceptibility loci have been identified for lung cancer in genome-wide association studies (GWASs), the susceptibility genes and underlying mechanisms remain unclear. In this study, we conducted a cross-tissue transcriptome-wide association study (TWAS) with UTMOST based on summary statistics from 13 327 lung cancer cases and 13 328 controls and the genetic-expression matrix over 44 human...

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PMID: 33909040
DOI: 10.1093/hmg/ddab119

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