Article
Dynamics of Plasma EGFR T790M Mutation in Advanced NSCLC: A Multicenter Study.
Targeted oncology - 1 Dec 2019
Yang Zhengquan, Li Jialu, Hu Yujie, Chen Meihua, Peng Danli, Zong Dan, Shang Qingjuan, Tao Lianqin, Zhao Yanling, Ni Yiyun, Ye Jinyan, Xie Yupeng, Yang Li, Lin Quan, Cai Chang, Xu Ning, Huang Xiaoping, Dong Xiaoting, Zhou Zhonghui, Yu Yali, Shangguan Zongxiao, Xu Yangyang, Ying Weiping, Weng Meiling, Yuan Zuguo, Dong Zhijun, Li Jifa, Zheng Zhe, Pan Jiongwei, Liu Lu, Ye Junhui, Zhang Zhan, Li Wenfeng, Zhu Junfei, Jin Shengnan, Li Yuping, Ding Chunming
Abstract excerpt
BACKGROUND: Droplet digital polymerase chain reaction (ddPCR) is an emerging technology for quantitative cell-free DNA oncology applications. However, a ddPCR assay for the epidermal growth factor receptor (EGFR) p.Thr790Met (T790M) mutation suitable for clinical use remains to be established with analytical and clinical validations. OBJECTIVE: We aimed to develop and validate a new ddPCR assay to quantify the...
Topics
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- Carcinoma, Non-Small-Cell Lung
- Case-Control Studies
- DNA
- Disease Progression