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Longitudinal monitoring of EGFR mutations in plasma predicts outcomes of NSCLC patients treated with EGFR TKIs: Korean Lung Cancer Consortium (KLCC-12-02).

Oncotarget - 9 Feb 2016

Lee Ji Yun, Qing Xu, Xiumin Wei, Yali Bai, Chi Sangah, Bak So Hyeon, Lee Ho Yun, Sun Jong-Mu, Lee Se-Hoon, Ahn Jin Seok, Cho Eun Kyung, Kim Dong-Wan, Kim Hye Ryun, Min Young Joo, Jung Sin-Ho, Park Keunchil, Mao Mao, Ahn Myung-Ju

Abstract excerpt

We hypothesized that plasma-based EGFR mutation analysis for NSCLC may be feasible for monitoring treatment response to EGFR TKIs and also predict drug resistance.Clinically relevant mutations including exon 19 deletion (ex19del), L858R and T790M were analyzed using droplet digital PCR (ddPCR) in longitudinally collected plasma samples (n = 367) from 81 NSCLC patients treated with EGFR TKI. Of a total 58 baseline...

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Identifiers

PMID: 26755650
DOI: 10.18632/oncotarget.6874
PMCID: PMC4872763

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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