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Detection and quantification of EGFR T790M mutation in liquid biopsies by droplet digital PCR

1 Mar 2021

Abstract excerpt

Background: Liquid biopsy allows the identification of targetable cancer mutations in a minimally invasive manner. In patients with advanced non-small cell lung cancer (NSCLC), droplet digital PCR (ddPCR) is increasingly used to genotype the epidermal growth factor receptor (EGFR) gene in circulating cell-free DNA (cfDNA). However, the sensitivity of this method is still under debate. The aim of this study was to...

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PMID: 33889502
DOI: 10.21037/tlcr-20-1010

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