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Article

Optimal method for quantitative detection of plasma EGFR T790M mutation using droplet digital PCR system.

Oncology reports - 1 May 2017

Suzawa Ken, Yamamoto Hiromasa, Ohashi Kadoaki, Hashida Shinsuke, Tomida Shuta, Kubo Toshio, Maki Yuho, Soh Junichi, Tsukuda Kazunori, Kiura Katsuyuki, Miyoshi Shinichiro, Toyooka Shinichi

Abstract excerpt

Though patients with EGFR mutations are initially responsive to EGFR-tyrosine kinase inhibitors (TKIs), most tumors ultimately acquire resistance to EGFR-TKIs. The most frequently reported mechanism is EGFR T790M mutation. In this study, using a droplet digital PCR (ddPCR) system, we assessed optimal conditions for a mutation detection assay for EGFR T790M obtained from circulating cell-free DNA (cfDNA) in...

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PMID: 28405680
DOI: 10.3892/or.2017.5567

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EGFR

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