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Article

Monitoring of T790M in plasma ctDNA of advanced EGFR-mutant NSCLC patients on first- or second-generation tyrosine kinase inhibitors.

BMC cancer - 13 Mar 2023

Huang Chun-Ta, Lin Chih-An, Su Te-Jen, Yang Ching-Yao, Tsai Tzu-Hsiu, Hsu Chia-Lin, Liao Wei-Yu, Chen Kuan-Yu, Ho Chao-Chi, Yu Chong-Jen

Abstract excerpt

BACKGROUND: The T790M mutation is the major resistance mechanism to first- and second-generation TKIs in EGFR-mutant NSCLC. This study aimed to investigate the utility of droplet digital PCR (ddPCR) for detection of T790M in plasma circulating tumor DNA (ctDNA), and explore its impact on prognosis. METHODS: This prospective study enrolled 80 advanced lung adenocarcinoma patients treated with gefitinib, erlotinib,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36915101
DOI: 10.1186/s12885-023-10698-5
PMCID: PMC10010021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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