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Article

Clinical implementation of circulating tumour DNA testing for EGFR T790M for detection of treatment resistance in non-small cell lung cancer.

Journal of clinical pathology - 1 Feb 2021

Spence Tara, Perera Sheron, Weiss Jessica, Grenier Sylvie, Ranich Laura, Shepherd Frances, Stockley Tracy L

Abstract excerpt

AIMS: Epidermal growth factor receptor (EGFR) T790M mutations can be detected in the circulating tumour DNA from plasma of patients with non-small cell lung cancer (NSCLC) to triage patients for osimertinib eligibility and monitor patients longitudinally for development of T790M-mediated resistance. METHODS: Using droplet digital PCR (ddPCR), we examined the EGFR T790M status of 343 sequential patients with NSCLC...

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Identifiers

PMID: 32471890
DOI: 10.1136/jclinpath-2020-206668
PMCID: PMC7841482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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