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Article

Prospective Validation of Rapid Plasma Genotyping for the Detection of EGFR and KRAS Mutations in Advanced Lung Cancer.

JAMA oncology - 1 Aug 2016

Sacher Adrian G, Paweletz Cloud, Dahlberg Suzanne E, Alden Ryan S, O'Connell Allison, Feeney Nora, Mach Stacy L, Jänne Pasi A, Oxnard Geoffrey R

Abstract excerpt

IMPORTANCE: Plasma genotyping of cell-free DNA has the potential to allow for rapid noninvasive genotyping while avoiding the inherent shortcomings of tissue genotyping and repeat biopsies. OBJECTIVE: To prospectively validate plasma droplet digital PCR (ddPCR) for the rapid detection of common epidermal growth factor receptor (EGFR) and KRAS mutations, as well as the EGFR T790M acquired resistance mutation....

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Identifiers

PMID: 27055085
DOI: 10.1001/jamaoncol.2016.0173
PMCID: PMC4982795

Genes

EGFR
KRAS
TAT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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