Article
Detection of the T790M mutation of EGFR in plasma of advanced non-small cell lung cancer patients with acquired resistance to tyrosine kinase inhibitors (West Japan oncology group 8014LTR study).
Oncotarget - 6 Sept 2016
Takahama Takayuki, Sakai Kazuko, Takeda Masayuki, Azuma Koichi, Hida Toyoaki, Hirabayashi Masataka, Oguri Tetsuya, Tanaka Hiroshi, Ebi Noriyuki, Sawa Toshiyuki, Bessho Akihiro, Tachihara Motoko, Akamatsu Hiroaki, Bandoh Shuji, Himeji Daisuke, Ohira Tatsuo, Shimokawa Mototsugu, Nakanishi Yoichi, Nakagawa Kazuhiko, Nishio Kazuto
Abstract excerpt
INTRODUCTION: Next-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been developed to overcome resistance to earlier generations of such drugs mediated by a secondary T790M mutation of EGFR, but the performance of a second tumor biopsy to assess T790M mutation status can be problematic. METHODS: We developed and evaluated liquid biopsy assays for detection of...
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